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Trimethoprim/ Sulfamethoxazole
Co-Trimoxazole - Septra, Bactrim
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Pocket Guide to Pediatric Drugs - Trimethoprim/Sulfamethoxazole |
5.112 - TRIMETHOPRIM/ SULFAMETHOXAZOLE (Rx)
(Co-Trimoxazole - Septra, Bactrim)
INDICATIONS:
- Acute otitis media caused by hemophilus influenza or streptococcus pneumoniae.
- Urinary tract infections caused by E.coli, proteus mirabilis, klebsiella or enterobacter.
DOSE:
- 8 mg/kg/day trimethoprim and 40 mg/kg/day sulfamethoxazole (1 ml/kg/day) given in equally divided doses q12h for 10 days.
DOSAGE GUIDELINES:
|
WEIGHT |
DOSE |
|
(Lb) |
(Kg) |
(Every 12 Hours) |
|
11 |
5 |
1/2 tsp |
|
18 |
8 |
3/4 tsp |
|
22 |
10 |
1 tsp (1/2 tab) |
|
33 |
15 |
1&1/2 tsp |
|
44 |
20 |
2 tsp (1 tab) |
|
66 |
30 |
3 tsp (1&1/2 tab) |
|
88 |
40 |
4 tsp (2 tabs or 1 DS tab) |
- Do not use in infants under 2 months of age, sulfonamides are contraindicated in this age group.
SUPPLIED:
- SUSPENSION:
- 200 mg sulfamethoxazole and 40 mg trimethoprim/5 ml, pink color. Cherry flavor.
- TABLETS:
- Single Strength: 400 mg sulfamethoxazole and 80 mg trimethoprim (equals 2 tsp of suspension).
- Double Strength: 800 mg sulfamethoxazole and 160 mg trimethoprim (equals 4 tsp of suspension).
COST:
- One of the least expensive antibiotics. Recommended as a cost effective first choice for indicated infections.
- Tablets = Tablets DS < Suspension.
- Generically available.
CAUTIONS:
- Not to be used for Group A B-Hemolytic streptococcal tonsillopharyngitis since it may not eradicate the infection and, therefore, may not prevent sequelae such as rheumatic fever.
- May cause nausea, vomiting, or diarrhea.
- May cause a skin rash or photosensitivity.
- Do not use in infants less than 2 months of age.
- May cause bone marrow suppression.
COMMENTS:
- May be taken on a full or empty stomach.
- Take with plenty of fluids.
- The suspension is stable without refrigeration for at least one year.
- Should not be used for otitis prophylaxis, amoxicillin or Gantrisin are preferred agents.
Monograph last updated: December 1st, 1999
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