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Cephalosporins, Oral
Cephalexin - Keflex, Cephradine - Anspor, Velosef
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Pocket Guide to Pediatric Drugs - Cephalosporins, Oral
5.134 - CEPHALOSPORINS, ORAL (Rx)
(Cephalexin - Keflex, Cephradine - Anspor, Velosef)

INDICATIONS:

  • Respiratory tract infections and skin and soft tissue infections caused by susceptible strains of staphylococci, streptococci, or pneumococci.
  • Otits media due to susceptible strains.

DOSE:

  • 25 - 50 mg/kg/day (11 - 46 mg/lb/day) in divided doses every 6 hours. 75 - 100 mg/kg/day (33 - 46 mg/lb/day) in divided doses every 6 hours for otitis media. Do not exceed 4 gm/day.
  • For streptococcal pharyngitis and skin and soft tissue infections, may give every 12 hours.
  • The usual course of therapy is 10 days.

DOSAGE GUIDELINES (50 mg/kg/day):

WEIGHT DOSE (given every 6 hours)
(Lb) (Kg) 125 mg/5 ml 250 mg/5 ml
11 5 1/2 tsp 1/4 tsp
22 10 1 tsp 1/2 tsp
33 15 1&1/2 tsp 3/4 tsp
44 20 2 tsp 1 tsp (250 mg cap)
66 30 -- 1&1/2 tsp
88+ 40+ -- 2 tsp (500 mg cap)

SUPPLIED:

  • SUSPENSION: 125 mg/5 ml, 250 mg/5 ml - 100 ml & 200 ml, flavored.
  • CAPSULES: 250 mg, 500 mg.

COST:

  • Moderately priced antibiotic.
  • Capsules < Suspension
  • Generically available.

CAUTIONS:

  • Use with caution in the penicillin-allergic patient.
  • Contraindicated in the cephalosporin-allergic patient.
  • May cause nausea, vomiting, diarrhea or rash.

COMMENTS:

  • May be taken on a full or empty stomach.
  • The suspension is stable for 14 days after mixing.
  • Refrigeration is required.

Monograph last updated: December 1st, 1999

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Copyright & Disclaimer: Every effort has been made to ensure that the information provided here and in our printed materials is accurate. The reader, however, is advised to verify drug dosage schedules with the latest manufacturer's product information insert prior to administration of the drug. Some dosage schedules have not been approved for inclusion in product package inserts and it is the prescribers responsibility to ascertain the suitability of these doses. The information presented here may not be complete and is not intended to take the place of professional advise. Contact your Doctor, Nurse, Pharmacist or other health professional for additional information.