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Amebicides, Metronidazole - Flagyl
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Pocket Guide to Pediatric Drugs - Amebicides |
5.5 - AMEBICIDES (Rx)
(Metronidazole - Flagyl)
INDICATIONS:
- Treatment of amebiasis, giardiasis, trichomoniasis and anaerobic infections.
DOSE:
- Dosage varies depending on the type of infection. Maximum dose is 4 gm per day.
- Amebiasis: Usual dosage is 35 - 50 mg/kg/day (16 -23 mg/lb/day) every 8 hours for 10 days up to the adult dose of 750 mg q8h.
- Giardiasis: Usual dosage is 15 mg/kg/day (6.8 mg/lb/day) every 8 hours for 7 days up to the adult dose of 250 mg q8h.
- Trichomoniasis: Usual dosage is 15 - 30 mg/kg/day (6.8-13.6 mg/lb/day) in divided doses every 8 hours for 7 days up to the adult dose of 250 mg every 8 hours or 2 gm as a single dose (older children weighing more than 50 kg or 110 lbs).
- Anaerobic Infections: Usual dosage is 15 - 35 mg/kg/day (6.8 -23 mg/lb/day) every 8 hours up to the adult dose of 500 mg every 6 - 8 hours.
DOSAGE GUIDELINES:
|
WEIGHT |
DOSE (given every 8 hours)
(portion of a 250 mg tablet) |
|
(Lb) |
(Kg) |
15 mg/kg/day |
35 mg/kg/day |
50 mg/kg/day |
|
14 |
6 |
1/8 tab |
1/4 tab |
3/8 tab |
|
27 |
12 |
1/4 tab |
1/2 tab |
3/4 tab |
|
55 |
25 |
1/2 tab |
1 & 1/4 tab |
1 & 3/4 tab |
|
82 |
37 |
3/4 tab |
1 & 3/4 tab |
2 & 1/2 tabs |
|
110 |
50 |
1 tab |
2 & 1/4 tabs |
3 tabs (2 tabs q6h) |
SUPPLIED:
COST:
- Relatively inexpensive, generically available medication.
CAUTIONS:
- Do not take anything containing alcohol for at least 24 hours after the last dose. May cause an antabuse-like reaction.
- May cause nausea, vomiting, diarrhea, headache, and an unpleasant metallic taste.
- May cause seizures, dizziness or confusion.
COMMENTS:
- Take with food. Tablets can be crushed and mixed with food.
- A suspension can be compounded if necessary but has a poor taste.
- May discolor the urine a dark brown.
- Pill splitters are available to cut tablets.
Monograph last updated:
December 1st, 1999 |
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