CH3
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| Afri-Cola 100 | Mello Yellow 52.8 | Shasta Cola 44.4 | RC Cola 36.0 |
| Jolt 71.2 | Surge 51.0 | Mr.Pibb 40.8 | Diet RC 36.0 |
Mt.Dew 55.0 |
Tab 46.8 | Dr.Pepper 39.6 | Diet Rite 36.0 |
Diet Mt Dew 55 |
Coca-Cola 45.6 | Pepsi 37.2 | Canada Dry 30.0 |
| Kick citrus 54 | Diet Coke 45.6 | Diet Pepsi 35.4 | Diet Canada Dry 1 |
Caffeine, the molecule = 1,3,7-Trimethylxanthine
CH3
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N----C....... C==O
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CH .....C........N--CH3
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...CH3....0.................
Contents:
1. Symptoms of Caffeine Withdrawal (this wont happen if you never quit!)
2. What happens when you overdose on Caffeine (it happens to everybody)
3. Can you die from to much Caffeine?
4. Symptoms of a Toxic Overdose of Caffeine
5. Can Caffeine make you live a longer happier life?
6. Caffeine, your metabolism, and why athletes do the Dew!
*** Be sure to check out these Caffeine Web Rings!***
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This Ring of Caffeine site |
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What are the symptoms of caffeine withdrawal?
Regular caffeine consumption reduces sensitivity to caffeine. When caffeine intake is reduced, the body becomes oversensitive to adenosine. In response to this oversensitiveness, blood pressure drops dramatically, causing an excess of blood in the head (though not necessarily on the brain), leading to a headache.
This headache, well known among coffee drinkers, usually lasts from one to five days, and can be alleviated with analgesics such as aspirin. It is also alleviated with caffeine intake (in fact several analgesics contain caffeine dosages).
Often, people who are reducing caffeine intake report being irritable, unable to work, nervous, restless, and feeling sleepy, as well as having a headache. In extreme cases, nausea and vomiting has also been reported.
References: Caffeine and Health. J. E. James, Academic Press, 1991. Progress in Clinical and Biological Research Volume 158. G. A. Spiller, Ed. Alan R. Liss Inc, 1984.
2.What happens when you overdose?
From Desk Reference to the Diagnostic Criteria from DSM-3-R (American Psychiatric Association, 1987):
Caffeine-Induced Organic Mental Disorder 305.90 Caffeine Intoxication
1.Recent consumption of caffeine, usually in excess of 250 mg. (Over 5 Mountain Dews in one hour)
2.At least five of the following signs: 1.restlessness 2.nervousness 3.excitement 4.insomnia 5.flushed face 6.diuresis 7.gastrointestinal disturbance 8.muscle twitching 9.rambling flow of thought and speech 10.tachycardia or cardiac arrhythmia 11.periods of inexhaustibility 12.psychomotor agitation
3. Not due to any physical or other mental disorder, such as an Anxiety Disorder.
Basically, overdosing on caffeine will probably be very unpleasant (although, I kind of like it) but not kill or deliver permanent damage. However, People do die from it.
The LD_50 of caffeine (that is the lethal dosage reported to kill 50% of the population) is estimated at 10 grams for oral administration. As it is usually the case, lethal dosage varies from individual to individual according to weight. Ingestion of 150mg/kg of caffeine seems to be the LD_50 for all people. That is, people weighting 50 kilos have an LD_50 of approx. 7.5 grams, people weighting 80 kilos have an LD_50 of about 12 grams.
In Mountain Dew the LD_50 is about 200 12 ounce cans or about 50 vivarins (200mg each).
One exceptional case documents survival after ingesting 24 grams. The minimum lethal dose ever reported was 3.2 grams intravenously, this does not represent the oral MLD (minimum lethal dose).
In small children ingestion of 35 mg/kg can lead to moderate toxicity. The amount of caffeine in an average cup of coffee is 50 - 200 mg. Infants metabolize caffeine very slowly.
•Acute caffeine poisoning gives early symptoms of anorexia, tremor, and restlessness. Followed by nausea, vomiting, tachycardia, and confusion. Serious intoxication may cause delirium, seizures, supraventricular and ventricular tachyarrhythmias, hypokalemia, and hyperglycemia. •Chronic high-dose caffeine intake can lead to nervousness, irritability, anxiety, tremulousness, muscle twitching, insomnia, palpitations and hyperreflexia. For blood testing, cross-reaction with theophylline assays will detect toxic amounts. (Method IA) Blood concentration of 1-10 mg/L is normal in coffee drinkers, while 80 mg/L has been associated with death.
Studies on the side-effects of caffeine.
OAKLAND, California (UPI) -- Caffeine may be good for life. A major study has found fewer suicides among drinkers of Caffeine than those who abstained from the popular stimulant. The study of nearly 130,000 Northern California residents and the records of 4,500 who have died looked at the effects of coffee and tea on mortality.
Cardiologist Arthur Klatsky said of the surprising results, ``This is not a fluke finding because our study was very large, involved a multiracial population, men, women, and examined closely numerous factors related to mortality such as alcohol consumption and smoking.''
The unique survey also found no link between coffee consumption and death risk. And it confirmed a ``weak'' connection of coffee or tea to heart attack risk -- but not to other cardiovascular conditions such as stroke.
The study was conducted by the health maintenance organization Kaiser Permanent and was reported Wednesday in the Annals of Epidemiology.
Caffeine increases the level of circulating fatty acids. This has been shown to increase the oxidation of these fuels, hence enhancing fat oxidation. Caffeine has been used for years by runners and endurance people to enhance fatty acid metabolism. It's particularly effective in those who are not habitual users.
Caffeine is not an appetite suppressant. It does affect metabolism, though it is a good question whether its use truly makes any difference during a diet. The questionable rationale for its original inclusion in diet pills was to make a poor man's amphetamine-like preparation from the non-stimulant sympathomimetic phenylpropanolamine and the stimulant caffeine. (That you end up with something very non-amphetamine like is neither here nor there.) The combination drugs were called "Dexatrim" or Dexa-whosis (as in Dexedrine) for a reason, namely, to assert its similarity in the minds of prospective buyers. However, caffeine has not been in OTC diet pills for many years per order of the FDA, which stated that there was no evidence of efficacy for such a combination.
From Goodman and Gilman's The Pharmacological Basis of Therapeutics: Caffeine in combination with an analgesic, such as aspirin, is widely used in the treatment of ordinary types of headache. There are few data to substantiate its efficacy for this purpose. Caffeine is also used in combination with an ergot alkaloid in the treatment of migrane (Chapter 39).
Still want more info on Caffeine? Check this out!
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